Linkage of the hepatitis C virus genotype and interleukin-28B genetic polymorphisms in Asian patients

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Role of Interleukin-28B Genetic Polymorphisms in Korean Patients with Hepatitis C Virus Infection

BACKGROUND/AIMS This study investigated the role of single nucleotide polymorphisms (SNPs) near the interleukin-28B (IL28B) gene with respect to clinical outcomes and the antiviral response in hepatitis C virus (HCV) infection to suggest the practical utility of IL28B genotyping in Korea. METHODS Two SNPs near IL28B, rs12979860 and rs8099917, were analyzed using an allelic discrimination assa...

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Hepatic STAT1-Nuclear Translocation and Interleukin 28B Polymorphisms Predict Treatment Outcomes in Hepatitis C Virus Genotype 1-Infected Patients

BACKGROUND We investigated associations between signal transducer and activator of transcription (STAT) 1 in pretreated liver tissues, interleukin (IL) 28B polymorphism and treatment response in hepatitis C virus (HCV)-infected patients treated with peginterferon and ribavirin. METHODS AND FINDINGS We performed immunostaining analysis of STAT1 in liver tissues and determined IL28B polymorphis...

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Association of interleukin-28B genotype and hepatocellular carcinoma recurrence in patients with chronic hepatitis C.

PURPOSE Several single-nucleotide polymorphisms (SNP) in the interleukin-28B (IL-28B) locus have recently been shown to be associated with antiviral treatment efficacy for chronic hepatitis C (CHC). However, such an association with hepatocellular carcinoma (HCC) is unkno3 we investigated the association between the IL-28B genotype and the biology and clinical outcome of patients with HCC recei...

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Association of Interleukin 28B genotype and hepatocellular carcinoma recurrence in patients with chronic hepatitis C Authors:

Purpose: Several single nucleotide polymorphisms (SNPs) in the interleukin 28B (IL28B) locus have recently been shown to be associated with antiviral treatment efficacy for chronic hepatitis C (CH-C). However, such an association with hepatocellular carcinoma (HCC) is unknown. Here, we investigated the association between the IL28B genotype and the biology and clinical outcome of HCC patients r...

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Lack of association between interleukin 28B polymorphisms and spontaneous viral clearance in hepatitis B virus patients.

TO THE EDITOR—We read the article by Seto et al [1] with interest. The authors investigated the correlation of HLA-DP and interleukin 28B (IL-28B) polymorphisms with hepatitis B surface antigen (HBsAg) seroclearance in hepatitis B virus (HBV) patients, and found that IL-28B haplotype CG (rs12979860/rs8099917) was associated with HBsAg clearance. The role of IL-28B polymorphisms in HBV has been ...

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ژورنال

عنوان ژورنال: Hepatology

سال: 2011

ISSN: 0270-9139

DOI: 10.1002/hep.24049